Antacids and cimetidine treatment for gastro-oesophageal reflux and peptic oesophagitis.
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چکیده
منابع مشابه
Antacids and cimetidine treatment for gastro-oesophageal reflux and peptic oesophagitis.
Thirty three children aged 2 to 42 months (mean 9 months) with gastro-oesophageal reflux and peptic oesophagitis took part in a treatment trial comparing cimetidine (20 mg/kg/day) with an intensive regimen of antacids (Maalox, 700 mmol (mEq)/1 X 73 m2/day). All children were evaluated clinically and by radiology, acid reflux test, and endoscopy. After 12 weeks of treatment all were again evalua...
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Twenty children (age range 75 days-47 months) with reflux oesophagitis entered a random double blind trial in which they received either Cisapride (Janssen Pharmaceutical Ltd), a new prokinetic agent, or an identical placebo syrup. Diagnosis of gastro-oesophageal reflux was made by measurement of intraluminal oesophageal pH combined with manometry. Oesophagitis was assessed in all patients by h...
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Twenty patients with reflux oesophagitis causing a tight peptic oesophageal stricture entered a randomised double-blind crossover trial in which they received cimetidine, 1.6 g daily, and matching placebo each for six months. The gross endoscopic appearances of oesophagitis, though not the grades of histopathological changes, showed significant improvement during treatment with cimetidine. The ...
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Fifty two patients were studied to investigate the patterns of gastro-oesophageal reflux during ambulatory pH monitoring and the relationship of reflux to presence and severity of oesophagitis. Twenty nine had evidence of oesophagitis which was graded according to severity. Acid exposure (pH less than 4) was calculated in each case for the total study period, the recumbent and upright periods, ...
متن کاملDiagnosis and treatment of gastro-oesophageal reflux.
Gastro-oesophageal reflux (GOR) is defined as the involuntary passage of gastric contents into the oesophagus, and is a common cause of morbidity in childhood. GOR is an occasional physiological event in normal adults and children,1 2 but becomes pathological when its intensity or frequency increases or when complications arise (for example, oesophagitis, failure to thrive). GOR may be primary ...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1984
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.59.9.842